SEJ_2-2017_Articol_Ngeow

                    ENDODONTICS
                    A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE”
Original Articles
                    AGAINST ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR
                    Wei Cheong Ngeow1a*, Dionetta Delitta Dionyssius1b, Hayati Ishak1b
                    1
                        Department of Oro-Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia

                    BDS (Mal), FFDRCS (Ire), FDSRCS (Eng), MDSc (Mal), PhD (Sheffield), FAMM
                    a

                    BDS (Mal)
                    b

                                                                                                                                                                                    Received: March 09, 2016
                                                                                                                                                                                        Revised: May 30, 2016
                                                                                                                                                                                     Accepted: June 29, 2016
                                                                                                                                                                                      Published: July 01, 2016

                    Academic Editor: Paula Perlea, DMD, PhD, Associate Professor, Dean, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania

                    Cite this article:
                    Ngeow WC, Dionyssius DD, Ishak H. A radiographic study to determine the possible existence of a “safe zone” against endodontic periapical extrusion
                    in the lower premolar. Stoma Edu J. 2017;4(2):108-113.
                    ABSTRACT                                                                                                                   DOI: 10.25241/stomaeduj.2017.4(2).art.3

                    Introduction: Studies have shown that the most common position of the mental foramen in several
                    Asian populations was in line with the apex of the second premolar. Therefore, we seek to determine
                    the average distance of the mental foramen to the apex of the second premolar by using the crown
                    length of the second premolar as a ruler. We hope to define a “safe zone” in this region.
                    Methodology: Measurements were made from the apex of the second premolar to the mental
                    foramen of ninety seven dental radiographs fulfilling the criteria set.
                    Results: Non-detection of mental foramina happened significantly more often in female subjects
                    than male (Pearson Chi-square; p=0.01). Of the mental foramina that were visible, 96% were found
                    to be located within one-crown distance from the apex. More mental foramina (37.1%; 56 sites)
                    were located at the apex than any other locations. This is followed by finding the mental foramina
                    located at ¼-crown distance from the apex (26.5%; 40 sites). The visibility of the mental foramen was
                    found to be significantly limited in females and in patients aged 50 and above (Pearson Chi-square;
                    p<0.05).
                    Conclusion: These findings suggest that there is no safe zone against accidental extrusion of
                    endodontic files and materials in the second premolar region.
                    Keywords: endodontology, complication, inferior alveolar nerve, mental nerve, mental foramen.

                    1. Introduction                                                                                         mental paraesthesia related to root canal treatment
                    The mental foramen is located close to the                                                              of mandibular premolar teeth. However, all these
                    mandibular premolars, especially the second                                                             incidents were related to periapical infection or
                    premolar.1 A morphometric study by Philips et al.2                                                      pathology, instead of being a complication of the
                    reported the mental foramen to be located on                                                            root canal treatment itself as the authors excluded 2
                    average at a distance of 2.18 mm mesially and 2.4                                                       (0.24%) cases of severe overfill and iatrogenic root
                    mm inferiorly from the plain radiographic apex of                                                       perforation with mechanical instrumentation into the
                    the second premolar. More precisely, the mental                                                         mental nerve.3
                    foramina could be located anywhere 3.8 mm mesially                                                      Eliminating infection in the pulp and dentin,
                    2.7 mm distally, 3.4 mm above or 3.5 mm below the                                                       followed by adequate intra-canal preparation
                    apex of the second premolar. Various cadaveric                                                          and proper sealing constitute the basic principles
                    studies reported the apices of the second premolars                                                     of root canal treatment. Ideally, mechanical
                    to be between 0 and 4.7 mm away from the mental                                                         preparation and filling should be limited within the
                    foramen.3,4 Using a newer technology of cone beam                                                       root canal as overinstrumentation or the extrusion
                    computed tomography (CBCT), BÜrklein et al.5 also                                                       of chemical fillings beyond the apical foramen to
                    reported similar findings, with an average distance of                                                  the adjacent nerve can give rise to NSD such as
                    4.2 mm. However, 3.2% of the mental foramen was                                                         paraesthesia or anaesthesia.7,8 Paresthesia related
                    directly in contact with the second premolar.                                                           to overinstrumentation usually resolves within
                    Because of this close proximity, various events                                                         several days.9 In addition, minor material extrusions
                    affecting the second premolar, such as odontogenic                                                      are generally well tolerated by the periradicular
                    infection and orthodontic, endodontic, periodontal                                                      tissues as long as they do not spread to the adjacent
                    or surgical misadventure, may result in the                                                             nerve.10 However, long-term NSD has been reported
                    neurosensory disturbance to the area innervated by                                                      in cases where the nerve fibre is lacerated due to
                    the mental nerve that exits the mental foramen.1,6 A                                                    overinstrumentation or in contact with toxic overfilled
                    retrospective study found an incidence of 0.96% of                                                      endodontic materials.8,11

                    *Corresponding author:
                    Professor Dr Wei Cheong Ngeow, Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
                    Tel: 603-79674862, Fax: 603-79674534, e-mail: ngeowy@um.edu.my




 108                                                                                                  Stoma Edu J. 2017;4(2): 108-113                                     http://www.stomaeduj.com
      A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE” AGAINST
                              ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR

As the close proximity of the apices of the                 a radiograph view-box. A transparent tracing paper




                                                                                                                          Original Articles
mandibular premolar to the mental foramen acts              was placed over the radiograph and fixed properly
as an important contributory factor for NSD when            to ensure it remain static in relation to the film. An
overinstrumentation or overfilling of endodontic            imaginary line was drawn to outline the second
materials happen, it is the aim of this study to            premolar. A line was drawn to join the mesial and
determine the distance of the mental foramen to             distal points of the cement-enamel junction (CEJ).
the second mandibular premolar tooth. We chose              Another line was drawn at the tip of the crown, parallel
to concentrate on the second premolar only as an            to the line joining the CEJs. A line vertical to both
earlier study has shown that most of the terminal end       these lines was then drawn. It represents the crown
of the inferior alveolar nerve is located in line with      height of the second premolar. A pair of caliper was
the apex of the second premolar.12 In this pilot study,     used to transfer this distance to a metal ruler to obtain
also conducted on a selected Malay population,              an exact measurement. This measurement was then
we seek to determine the average distance of                divided by 4 (calculated to the nearest millimeter) to
the mental foramen from the apex of the second              give the height of a quarter-crown. The distance from
premolar by using the crown height of the second            the mental foramen to the apex was measured using
premolar as a ruler. The identification of this distance,   the second premolar crown height as a ruler (Fig. 1)
will hopefully enable us to come up with a so called        and was categorised as below:
“safe zone” to ensure that root canal treatment in
the lower premolar region can be performed with             I.       located at apex
minimum complications in case files or endodontic           II.      within ¼-crown-distance
filling materials are accidentally extruded beyond          III.     within ½-crown-distance
the apices of these premolars.                              IV.       within ¾-crown-distance
                                                            V.       within 1-crown-distance
2. Methodology                                              VI.      within 1½ -crown-distance
2.1. Materials		                                            VII.     within 2- crowns-distance
One hundred twenty panoramic radiographs of                 VIII.    Could not be identified
Malay patients of 4 different age-groups, taken
between 2003 and 2005 were obtained from the
records stored by the Dental Faculty of the University
of Malaya, Kuala Lumpur, Malaysia. The age-groups
were categorised as 20-29 years-old, 30-39 years-
old, 40-49 years-old and 50 years and above.
All panoramic radiographs were taken using
Siemen Orthophos® (Sirona, Bensheim, Germany)
or Planmeca® (Planmeca, Helsinki, Germany)
machines. The magnification factors reported by the
manufacturers were 1.2 and 1.25, respectively. The
radiographs were chosen according to the following
criteria:
1. High quality with respect to geometric accuracy
and contrast of the image.
2. Radiographs in which the lower teeth (between
36 and 46) were missing, had deep caries, root
canal treatment or various restorations were
excluded because of possible associated periapical
                                                              Figure 1. An illustration showing the method used to
radiolucency.                                               determine the distance of the mental foramen to the apex of
3. Radiographs must be free from any radiolucent or         the second premolar using the crown height as a ruler
radiopaque lesion in the lower arch. There should           (Note: In this dental panoramic radiograph, the mental
be no evidence of jaw fracture around the mental            foramen is located at the apex of the second premolar).
foramen region.
4. Radiographs with supernumeraries and unerupted           3. Results
teeth were excluded because the impacted/                   There were a total of 97 radiographs with bilateral
unerupted teeth might obscure the appearance of             sites that fulfilled the criteria and were examined.
mental foramen.                                             Thirty-one of the subjects fell into those aged
5. Films should be devoid of any radiographic               between 20-29 years, 24 subjects were between
exposure or processing artefacts.                           30-39 years old, 22 between 40-49 years old and
6. Radiographs where the lower canine was missing           the final 20 were aged 50 years and above. The
were excluded because of the possibility of mesial          number of subjects (hence radiographs) that fulfilled
premolar drift.                                             the criteria set became less with the age increase as
7. Radiographs in which the upper premolars were            there was a high number of subjects who become
missing were excluded because of the possibility of         fully edentulous or partially edentulous beginning
overeruption of the lower premolars.                        from the first premolar.
2.2. Methods                                                The mental foramen was visible in 77.8% (151) of the
The dental panoramic radiographs were placed on             sites reviewed. It was slightly more pronounced on



Stomatology Edu Journal                                                                                                    109
                    A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE” AGAINST
                    ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR
Original Articles    Table 1. Distribution for location of mental foramina according to age-groups.



                    Location                     20-29 years       30-39 years       40-49 years                              ≥ 50 years
                                             [site/percentage] [site/percentage] [site/percentage]                     [site/percentage]

                    Apex                          23 (37.1%)              17 (35.4%)                  9 (20.4%)                7 (17.5%)

                    ¼-crown                       14 (22.6%)              11 (22.9%)                  11 (25%)                   4 (10%)

                    ½-crown                        4 (6.4%)                5 (10.4%)                  3 (6.8%)                    0 (0%)

                    ¾-crown                        4 (6.4%)                 2 (4.2%)                  11 (25%)                    2 (5%)

                    1-crown                        6 (9.7%)                7 (14.6%)                  2 (4.5%)                  3 (7.5%)

                    1½-crown                        0 (0%)                  2 (4.2%)                  1 (2.3%)                  3 (7.5%)

                    2-crown                         0 (0%)                   0 (0%)                    0 (0%)                     0 (0%)

                    Not visible                   11 (17.8%)                4(8.3%)                   7 (16.0%)               21 (52.5%)

                    the left (80.5%; 78 sites) than the right side (75.3%;        Age-wise, all mental foramina were noted to be
                    73 sites) of the mandible. Out of the mental foramina         located within a one-crown distance from the apex
                    that were visible, 96% were found to be located               in panoramic radiographs of subjects aged 20-29
                    within a one-crown distance from the apex. More               years. However, between 84.2% and 95.4% of them
                    mental foramina (37.1%; 56 sites) were located at the         were located within a one-crown distance for the
                    apex than at any other locations. This is followed by         remaining 3 age groups.
                    finding the mental foramina located within a ¼-crown          Figure 2 shows the distribution of the mental
                    distance from the apex (26.5%; 40 sites).                     foramina according to the gender of the subjects.
                    Table 1 shows the overall distribution of mental              The majority of the foramina were located within a
                    foramen according to various age groups. The                  one-crown distance from the apex, irrespective of
                    mental foramina were visible in the majority of               gender (female 95.4%; male 96.5%). The apex of the
                    panoramic radiographs of subjects under the age               second premolar was the most common location
                    of 50 years (20-29 years: 82.3%; 30-39 years: 91.7%;          for finding mental foramen in both genders (female
                    40-49 years: 84.1%). However, they did not become             40.9%; male 34.1%). However, there were gender
                    visible in more than half (52.5%) of panoramic                differences for other locations, with the ¼-crown
                    radiographs of subjects aged 50 and above. This               distance being the second most common for female
                    finding is statistically significant (Pearson Chi-square;     but ¼- and ¾-crown distance for the male. When
                    p<0.001)                                                      the mental foramina were not observed, more of




                     Figure 2. Distribution of the mental foramina according to the gender of the subjects.




 110                                                                 Stoma Edu J. 2017;4(2): 108-113            http://www.stomaeduj.com
      A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE” AGAINST
                              ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR

this happened in panoramic radiographs of female             magnification from 10% to 30%, image distortion and




                                                                                                                          Original Articles
subjects (28 sites) than male (15 sites). This difference    invisibility in the facio-lingual dimension. Therefore,
was statistically significant (Pearson Chi-square;           measuring directly on different radiographs taken
p=0.01)                                                      using different machines with different distortion
                                                             would result in a compromised finding. However, by
4. Discussion                                                calculating a ratio based on the crown height as a tool
Neurosensory disturbance (NSD) after root canal              of measurement, it is hoped that this will ensure that
treatment is an outcome of a rare accident at the            we are always consistent in relating distance between
apical region of the mandibular posterior teeth.             the mental foramen and the apex of the second
Numerous reports have been published describing              premolar. This ratio can be used to provide a mental
the occurrence of NSD during and after endodontic            picture of the distance available based on the average
treatment of the mandibular premolars7,8,13,14 with          crown height of a mandibular second premolar of 8.2
the possible mechanisms attributed to 3 factors,             mm, with a crown to root ratio of 1:1.8.17
namely mechanical, chemical, and thermal damage.             Translating the finding that 96% of mental foramina
Mechanical damage results from compression that              were found to be located within one-crown distance
occurs during overinstrumentation or by the filling          from the apex, this can easily suggest that a majority
material forced into the mandibular canal.15 Chemical        of the mental foramina were located within a 8.2 mm
damage, on the other hand, happens where there               perimeter from the apices of the second premolar.
is an extrusion of cytotoxic products used during            Worse, almost two-thirds (63.6%) of the mental
root canal preparation (irrigation and/or root canal         foramina were located either at the apex or within
medication) or obturation while thermal damage               a quarter crown-height distance from the apex,
is related to a lack of control in thermocompaction          translating to a ‘safe zone’ between 0 to 2 mm only!
filling techniques.9,16                                      Nevertheless, the distance recorded in this study is
The close proximity of the apices of the mandibular          still larger than that reported by Phillips et al.2 where
premolar and molar teeth to the mental foramen and           the centre of the mental foramen was located on an
mandibular canal fascilitate NSD to happen when              average distance of 2.18 mm mesially and 2.4 mm
overinstrumentation or overfilling of endodontic             inferiorly from the radiographic apex of the second
materials happened.1,15 In the molar/premolar                premolar. Our finding, together with that reported by
region, the inferior alveolar nerve describes a curve        Phillips et al.2 earlier, suggests that there is no really
that brings the second premolar as well as the               “safe zone” against accidental extrusion of endodontic
second molar root apices in closest proximity to the         files and materials in the second premolar region.
nerve.4 Not many researchers have looked into the            Two secondary findings that are statistically significant
distance of the premolar teeth to the terminal end of        are the fact that more mental foramina were not
the inferior alveolar nerve, namely the mental nerve         noticeable in female patients and in patients aged
and its foramen.2,3,4,5 Worse all of these studies were      more than 50 years old. The latter finding has been
undertaken on Caucasian subjects. We, therefore, feel        reported in an earlier publication.18 The effect of
it is timely to study this relationship in Asia due to the   gender on non-visibility of mental foramen has not
fact that endodontic extrusions with complication are        been reported, and could be related to the difficulty
still being reported every now and then. We hoped to         to distinguish it from trabeculae pattern in these
define a “safe zone” apical to the mandibular second         patients, in addition to poor radiograph quality (over
premolar, if one indeed exists.                              dark radiographs).19 As osteoporosis affects female
Bürklein et al.5 recently undertook such a study             subjects more than males, it is possible that is a
using data generated from cone beam computed                 potential contributing factor although this suggestion
tomography. However, CBCT is not as widely used              remains a hypothesis due to the fact that we did not
in our centre, and we instead have a huge archive            actively seek to determine if these subjects were
of data stored in panoramic radiographs. Hence               indeed having bone metabolism disorder.
we decided to study the premolar-mental foramen
relationship in panoramic radiographs as this is still       5. Conclusion
relevant clinically. However, as measurement done            More mental foramina were significantly not visible
on panoramic radiographs is generally considered             in panoramic radiographs of female subjects than
distorted, it was decided that the crown height was          male. Of mental foramina that were visible, 96% were
used as a comparative ruler because of two reasons:          found to be located within one-crown distance from
a) the inability to accurately measure the length/           the apex. Almost two-thirds (63.6%) of the mental
distance as these images were in hard copies, as             foramina were located either at the apex or within
opposed to the newer machine with a measuring                a quarter crown-height distance from the apex. The
software, and                                                visibility of the mental foramen was found to be
b) for clinical application sake, whereby it was felt that   significantly limited in patients aged 50 and above.
dentists/endodontists may want to have a mental              These findings suggest that there is no “safe zone” for
map of the “safe zone” around the premolar region,           accidental extrusion of endodontic files and materials
which can easily be related to the crown-height of the       in the second premolar region.
tooth concerned. This may become important when
only a periapical radiograph is taken for endodontic         Acknowledgments
purpose.                                                     The authors report no conflict of interest and there
It is well accepted that dental panoramic radiographs        was no external source of funding for the present
have some disadvantages, namely, variable                    study.



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                    A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE” AGAINST
                    ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR


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                                                                                                     Wei Cheong NGEOW
                                                                   BDS (Mal), FFDRCS (Ire), FDSRCS (Eng), MDSc (Mal)
                                                                                  PhD (Sheffield), FAMM, Professor Dr
                                                                   Department of Oral & Maxillofacial Clinical Sciences
                                                                              Faculty of Dentistry, University of Malaya
                                                                                                 Kuala Lumpur, Malaya


                    CV
                    Professor Dr Wei Cheong Ngeow graduated from the Faculty of Dentistry of the University of Malaya
                    in 1992 and went into private practice before being offered a tutorship at his alma matter. In 1996, he
                    obtained his Fellowship in Dental Surgery from the Royal Colleges of Surgeons in Ireland and England,
                    respectively. Back in Malaysia he was a pioneer lecturer at the newly established Universiti Kebangsaan
                    Malaysia. He returned to private practice in 1999 but in 2000 returned to the University of Malaya He
                    obtained an MDSc (2008) and a PhD from the University of Sheffield (2010). He has published over
                    160 articles, letters, comments and reports in local and international journals, and was the Editor of the
                    Malaysian Dental Journal (2005-2007) and Editor of the MDA Newsletter (2015). His research interests
                    are craniofacial anthropometry, variations of the mandibular nerve, recovery of peripheral nerves after
                    microsurgical repair.




 112                                                                     Stoma Edu J. 2017;4(2): 108-113            http://www.stomaeduj.com
     A RADIOGRAPHIC STUDY TO DETERMINE THE POSSIBLE EXISTENCE OF A “SAFE ZONE” AGAINST
                             ENDODONTIC PERIAPICAL EXTRUSION IN THE LOWER PREMOLAR


Questions




                                                                                                  Original Articles
1. Which tooth is usually closely related to the mental foramen?
qa. First premolar;
qb. Second premolar;
qc. First molar;
qd. Second molar.

2. Which of the following statements is not the main principle of endodontic treatment?
qa. Eliminating pain;
qb. Eliminating infection in pulp and dentine;
qc. Achieving adequate intracanal preparation;
qd. Achieving proper seal.

3. The following is not a factor that contributes to the occurrence of neurosensory disturbance
during endodontic treatment of the mandibular premolars:
qa. Mechanical;
qb. Chemical;
qc. Thermal;
qd. Psychological.

4. When translating the finding that 96% of mental foramina were found to be located within
one-crown distance from the apex, how far are the majority of the mental foramina located
within from the apices of the second premolar?
qa. 6 mm;
qb. 7 mm;
qc. 8 mm;
qd. 9 mm.




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