STOMATOLOGY EDU JOURNAL

COMMUNITY DENTISTRY

Efficacy of Bioflavonoids of FLAVOBAC™ Against Severe Acute Respiratory Syndrome – Coronavirus 2 In Vitro

DOI: https://doi.org/10.25241/stomaeduj.2021.8(2).art.1

Abstract

Introduction The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic of Coronavirus disease-2019 (COVID-19). Human-to-human transmission occurs mainly through the aerosolization of respiratory droplets. Improved antisepsis of human and non-human surfaces has been identified as a key feature of transmission reduction. Flavobac, a complex of soluble bioflavonoids and hydroxylated phenolic structures used in oral care products, has demonstrated efficacy to act against microorganisms. This study evaluated nasal and oral antiseptic formulations of FLAVOBAC for the virucidal activity against SARS-CoV-2.
Methodology FLAVOBAC nasal antiseptic formulations and FLAVOBAC oral rinse antiseptic formulations from 1-10% concentrations were assayed for virucidal efficacy against the SARS-CoV-2 virus. SARS-CoV-2 was exposed directly to the test compound for 60 seconds or 5 minutes. Compounds were then neutralized, and the surviving virus was quantified.
Results All concentrations of nasal antiseptics and oral rinse antiseptics evaluated completely inactivated the SARS-CoV-2 virus.
Conclusion Nasal and oral FLAVOBAC solutions are effective at inactivating the SARS-CoV-2 virus at a variety of concentrations after 60-second or 5-minute exposure times. The formulations tested have the potential to reduce the transmission of SARS-CoV-2 if used for nasal/oral decontamination, or surface decontamination in known or suspected cases of COVID-19.

Keywords
Bioflavonoid; COVID-19; Flavobac, SARS-COV-2; Virucidal Activity.

Figures are shown in pdf document

| (read pdf) |

PUBLISH WHIT US

We are celebrating 10 years of continuous publication and 30 issues released!
For over ten years, the Stomatology Edu Journal (Stoma Edu J) has been publishing for academic readers, scholars, and general dental practitioners.

If you have reviewed the current issue and found articles of interest, we invite you to submit your own paper to the Stomatology Edu Journal for the next issue at

Your choice is supported by the following arguments offered by the Stomatology Edu Journal:

Fast — rapid review and publication

Rigorous — peer-reviewed by at least two members of the academic community

Open — articles are freely available to all

Visible — enhanced browsing and searching to ensure your article is noticed

Global — worldwide media coverage

STATEMENT

STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a new international dental journal whose main purpose is to inform researchers, educators, graduates, postgraduates and practitioners about the latest trends in the field, which followed, would bring immediate and lasting benefits to the patients; and about opinions of the most authorized specialists on what is best in current practice, for the good of both, patient and dentist.
STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a peer-reviewed, open access international dental journal to be database indexed, meant to contribute to the development and completion of the medical training of practitioners as Dr. Greene Vardiman Black stated: “the professional man has no right to be other than a continual student”.
Open access journal, means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.