STOMATOLOGY EDU JOURNAL

RESTORATİVE DENTİSTRY

Dentin degradomics in dentin erosion

DOI: https://doi.org/10.25241/stomaeduj.2022.9(1).art.6

Günçe Ozan1a* , Meriç Berkman2b , Hande Șar Sancaklı1c

1Department of Restorative Dentistry, Faculty of Dentistry, Istanbul University, TR-34116 Fatih/Istanbul, Turkey
2Department of Restorative Dentistry, Faculty of Dentistry, Bahçeşehir University, TR-34349 Beşiktaş/İstanbul, Turkey

aDDS, PhD, Research Assistant; e-mail: gunce.saygi@istanbul.edu.tr; ORCHID ID: https://orcid.org/0000-0003-1018-3173
bDDS, PhD, Assistant Professor; e-mail: mericberkman@gmail.com; ORCHID ID: https://orcid.org/0000-0002-9269-4868
cDDS, PhD, Professor; e-mail: handesar@istanbul.edu.tr; ORCHID ID: https://orcid.org/0000-0001-8063-0413

Abstract
Background Dentin degradomics are the enzymes found in dentin endogenously and are aimed at attacking organic compounds of the relevant tissue. During dentin demineralization, these enzymes could turn into the reaction phase and may step up the degradation. Thus, their connection with dentin erosion and tissue loss should be explained.
Objective The aim of this review was to describe the mechanisms of dentin degradomics, their relation to dentin erosion, and recent approaches on inhibiting their action.
Data sources A narrative review was performed with a literature search in the PubMed and Google Scholar electronic databases.
Study selection Reference lists included full papers of any study design, published in peer-reviewed journals in English till November 2021.
Data extraction Current literature indicates the term of dentin degradomics, and the mechanism of dental erosion of both enamel and dentin tissues. The inhibition of matrixmetalloproteinase (MMP) enzymes, which constitute the subgroup of dentin degradomics, was gained from the recent papers listed in the reference section.
Data synthesis Biocorrosion covers more of the pathological process of the tissue loss however, most of the dentin degradomics such as MMPs are not covered by the term, biocorrosion. So, the definitions of biocorrosion and dentin degradomics were discussed in detail. Green tea, chlorhexidine and fluorides have the ability to inhibit the reaction of MMPs during dentin demineralization with a different state of mechanisms. Nowadays, other naturally-derived compounds were included in studies such as polyphenols and flavonoids. Still, more studies are necessary to clarify their mechanism of action and rates of efficiency.

Keywords
Dental Erosion; Dentin Degradomics; Biocorrosion; MMP İnhibitors; Polyphenols.

GREEN OPEN ACCESS

The Stomatology Edu Journal (Stoma Edu J) is one of the first Green Open Access journals in the field of dental medicine, publishing well-established authors, but equally committed to encouraging early career researchers and professionals alike to publish their work after a non-partisan, objective, double-blind rigorous peer-reviewed process. The Stomatology Edu Journal (Stoma Edu J) is a Green Open Access journal accessible for free on the Internet, hence no processing, peer review fees or article publishing charges payable by the author are required. A Green Open Access (GOA) journal means that all content is freely available to the user or his/her institution without charge. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. Our aim is to publish in the shortest possible time frame and ensure the rapid dissemination of your work via our journal page, but also through our indexing partners…(read more)

STATEMENT

STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a new international dental journal whose main purpose is to inform researchers, educators, graduates, postgraduates and practitioners about the latest trends in the field, which followed, would bring immediate and lasting benefits to the patients; and about opinions of the most authorized specialists on what is best in current practice, for the good of both, patient and dentist.
STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a peer-reviewed, open access international dental journal to be database indexed, meant to contribute to the development and completion of the medical training of practitioners as Dr. Greene Vardiman Black stated: “the professional man has no right to be other than a continual student”.
Open access journal, means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.