10.25241/stomaeduj.2018.5(3).art.4 – abstract

ORAL MEDICINE

Salivary matrix metalloproteinases activity levels in autoimmune diseases

DOI: https://doi.org/10.25241/stomaeduj.2018.5(3).art.4

Abstract

Introduction: It is widely recognized that saliva represents a solid alternative as a diagnostic fluid in a wide range of oral and general diseases. Autoimmune diseases constitute an important health threat to both men and women worldwide with matrix metalloproteinases (MMPs) playing significant roles in pathogenesis and development of these diseases. The specific aim of the present study is to asses, for the first time, salivary levels of a selected panel of MMPs in several autoimmune diseases.

Methodology: The study included 30 patients divided into groups such as: systemic sclerosis, vasculitis and healthy subjects. Salivary levels of MMP-1, -2, -7, -9 and -10 were analyzed using magnetic bead-based multiplex assays and Luminex technology.

Results: MMP-2 salivary levels were statistically elevated in systemic sclerosis, while MMP-10 were also increased in vasculitis patients. Salivary levels of MMP-9 were found significantly increased in all analyzed groups.

Conclusion: Taken together, our results promote saliva as a reliable diagnostic fluid for quantifying MMPs in autoimmune diseases.

Keywords: saliva, autoimmune diseases, matrixmetalloproteinase, vasculitis, systemic sclerosis.

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STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a new international dental journal whose main purpose is to inform researchers, educators, graduates, postgraduates and practitioners about the latest trends in the field, which followed, would bring immediate and lasting benefits to the patients; and about opinions of the most authorized specialists on what is best in current practice, for the good of both, patient and dentist.
STOMATOLOGY EDU JOURNAL (Stoma Edu J) is a peer-reviewed, open access international dental journal to be database indexed, meant to contribute to the development and completion of the medical training of practitioners as Dr. Greene Vardiman Black stated: “the professional man has no right to be other than a continual student”.
Open access journal, means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.